Composition |
Each tablet contains 100 mg allopurinol. Each tablet contains 300 mg allopurinol. |
Side effect |
- Increase of acute attacks of gout ( rarely). - Rash ,Itching. - Gastro intestinal disturbances ( nause, vomiting, slight a symptomatic SGOT/ SGPT increase ). |
Properties |
DAM LORIC is a xanthine oxidase inhibitor. It inhibits the oxidation of hypoxanthine which usually produces xanthine and uric acid. So this product decrease uric acid level in blood and urine. |
Therapeutic indications |
This product is indicated in : 1- Chronic gout. 2- While the treatment of neoplastic diseases . 3- Management of recurrent calcium oxalate renal stones in patient with hyperuricosuria. |
Contraindication |
Patients who have developed a severe reaction to allopurinol should not be treated with the drug. |
Warnings and precautions |
1- Should be discontinued at the first appearance of skin rash which may indicate an allergic reaction. 2- The drug should be used with care during pregnancy only if the doctor estimates that it is absolutely needed. 3- The drug has been found in the milk of nursing mothers, caution should be taken while lactation. 4- Should not be used in acute gout attack. 5- Caution in renal and liver insuffiency . 6- It is recommended to drink suitable quantity of water (2-3) liter to decrease the danger of renal stones. |
Drug interactions |
1- Increased azathioprin and mercaptopurine toxicity, in concomitant use with DAMLORIC. 2- Avoid concurrent usage with Aspirin and other salisylate. 3- It is possible to increase the toxic effect of some medications like Hypoglycemics, Oral Anticoagulants, Cyclosporin . 4- Monitor renal function with Thiazides. |
DOSAGE & ADMINISTRATION |
Adults: (2-10) mg/kg 100 - 300 mg/day, for patients with mild gout. 300 - 600 mg/day, in moderate cases of gout. 600 - 900 mg/day, for sever gout. |
Package |
30 Tablets of 100 mg Allopurinol. 30 Tablets of 300 mg Allopurinol. |