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Damloric 300 ( Allopurinol )

  • Effective Material
    Allopurinol 300 mg
  • Caliber
    300 mg
  • Pharmacologic Form
    - xanthine oxidase inhibitor
  • Therapeutic Categories
    Urological Drugs
  • Pharmaceutical Form
    Tablets
Composition
Each tablet contains 100 mg allopurinol.
Each tablet contains 300 mg allopurinol.
Side effect
- Increase of acute attacks of gout ( rarely).
- Rash ,Itching.
- Gastro intestinal disturbances ( nause, vomiting, slight a symptomatic SGOT/ SGPT increase ).
Properties
DAM LORIC is a xanthine oxidase inhibitor. It inhibits the oxidation of hypoxanthine which usually produces xanthine and uric acid. So this product decrease uric acid level in blood and urine.
Therapeutic indications
This product is indicated in :
1- Chronic gout.
2- While the treatment of neoplastic diseases .
3- Management of recurrent calcium oxalate renal stones in patient with hyperuricosuria.
Contraindication
Patients who have developed a severe reaction to allopurinol should not be treated with the drug.
Warnings and precautions
1- Should be discontinued at the first appearance of skin rash which may indicate an allergic reaction.
2- The drug should be used with care during pregnancy only if the doctor estimates that it is absolutely needed.
3- The drug has been found in the milk of nursing mothers, caution should be taken while lactation.
4- Should not be used in acute gout attack.
5- Caution in renal and liver insuffiency .
6- It is recommended to drink suitable quantity of water (2-3) liter to decrease the danger of renal stones.
Drug interactions
1- Increased azathioprin and mercaptopurine toxicity, in concomitant use with DAMLORIC.
2- Avoid concurrent usage with Aspirin and other salisylate.
3- It is possible to increase the toxic effect of some medications like Hypoglycemics, Oral Anticoagulants, Cyclosporin .
4- Monitor renal function with Thiazides.
DOSAGE & ADMINISTRATION
Adults: (2-10) mg/kg
100 - 300 mg/day, for patients with mild gout.
300 - 600 mg/day, in moderate cases of gout.
600 - 900 mg/day, for sever gout.
Package
30 Tablets of 100 mg Allopurinol.
30 Tablets of 300 mg Allopurinol.